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ABSTRACT
Beside eicosanoid and autocoid systems,
ENDOTHELIUM represents extremely complex regulatory system, with
surface more than 1000 m.
Endothelium cells constituted major PARACRINE human organ. having
a synthesis, release and/or activation of substances with procagulant,
anticoagulant, fibronlytic, hemotactic, inflamatory, vasodilatory
and vazoconstrictive actions. The highlights of these substances
are about better understandings of autocrine, jucstacrine and paracrine
controls, as well as endocrine regulation and intercellular response.
The study of endothelium system and its relation with platelets,
monocytes and smooth muscle cells of the vascular wall presents
the main study of major research groups over the world, as well
as in our country.
For the last few years it has been made a significant scientific
improvement in order to highlight of HOMEOSTASIS mechanism, disorder
of regulatory mechanisms in ATHEROSCLEROSIS and THROMBOSIS developing.
On the basis of research work over years we have postulated a special
concept about significance of balance inbetween PGI
and TXA
and their keeping fluidity and blood flow at homeostasis and preventing
of ahterosclerosis and thrombosis developing.
We have been explored anti-sclerotic effects of PGI
besides its vasodilataory, antiaggregatory, cytoprotective and fibrinolytic
effects.
PGI
and TXA
misbalance have a crucial role in pathogenesis of atherosclerose
as well as oxidized lipoproteins, endothelium cells, smooth muscle
cells and monocytes interaction.
This system INHIBITS basic mechanism of early atherosclerosis pathogenesis
such as mytogen liberation and holesterol esters accumulation. The
role of eicosanoid and autocanoid systems at inflammatory process
presents the theme of our investigations besides atherosclerosis
and thrombosis.
*Toxic Oxygen Metabolites
Keywords: endothelium, inflammation, atherosclerosis
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