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ABSTRACT
Preeclampsia represents a specific
syndrome, which is characterized by elevating arterial blood pressure,
proteinuria and edema. The aim of this study was to investigate
a nitric oxide level in preeclamisa and consequently endothelial
(dys) function, and free oxygen radical levels.
Our study were involved 18 healthy (control) and 19 pregnant women
with preeclamsia. The diagnosis of preeclampsia was done according
to recommendation of International Society for the Study of Hyperternsion
in Pregnancy. The next parameters were determined: (a) concentrations
of nitrite (NO-),
(b) concentrations of superoxide anion radical (O2-.), and (c) concentrations
of hydrogen peroxide (H2O2), in pregnant women plasma.
The results of our study shown that nitrite and L-arginine plasma
level of healthy pregnant woman were 5.84%, whereas in plasma of
pregnant women with preeclamsia were lower for 62% (p<0.01) and
33% (p<0.05), respectively. Superoxide anion radical and hydrogen
peroxide plasma level of pregnant women with preeclamsia were higher
for 19% (p<0.05) and 57% (p<0.01) respectively, related to plasma
levels of helathy pregnant women (20.1% and 30.64%).
Our study suggested that there were no strong oxidative stress during
preclamsia. Decreased NO concentration was, probably, the result
of endothelium dysfunction during preeclamsia, and affected inactivation
of free oxygen radicals.
Keywords: preeclampsia, nitric oxide, endothelium
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Correspondence to:
Ass dr Goran M Babic
Clinics of Obstretics and Gynaecology, Clinical Hospital Centre Kragujevac,
34000 Kragujevac, P.O.B. 124, Yugoslavia
e_mail: vlada@medicus.medf.kg.ac.yu
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